Post
by Dimas » Mon Mar 03, 2008 13:01
Umka
I've also bought melaxen himself,on this night, the first time I tried...slept very shallow,woke up a few times but the dreams were vivid and I remember much...must grimstalker to try...
That's interesting about it is written:
MELATONIN IS A UNIVERSAL REGULATOR OF LIFE
L. Jordanov, corresponding member. RAMS
Professor A. Gladkov, academician ramtn
Melatonin (a pineal hormone) in recent years has attracted the attention of many scientists in the world. He is considered one of the most important hormonal substances in the body. Obtained convincing evidence that melatonin is involved in almost all processes of life, controls many body functions: sleep, activity of the cardiovascular and immune systems.
One of the reasons that about melatonin for a very long time virtually nothing was known, is that the level of biochemical research simply did not allow to detect such a small amount of the substance in the bloodstream. Only in the mid 70-ies, with the development of technology radioimmunoassay analysis, the opportunity of detection of melatonin in the blood. After a few years, surveyed hundreds of people and received a presentation about the changes in melatonin concentration during the day and during the life cycle of a person. It turned out that the night concentration of melatonin in the blood is five to ten times more than during the day. He began to stand out after dark - about 8 o'clock in the evening, peaks at two or three o'clock in the morning, and then the amount is gradually reduced and at about seven o'clock in the morning and evening remains very low. In this regard, the researchers raised the question: how such fluctuations in the concentration of melatonin are associated with different physiological processes?
It turned out that the amount of melatonin varies not only during the day but also throughout a person's life. Melatonin, the child begins to stand shortly after birth and its concentration increases up to one year. After a year and before the onset of puberty melatonin synthesis remains at a constant and relatively high level, and then the amount is quite sharply reduced and continues to decrease for another five years. After that, changes in the formation of melatonin does not occur until forty or forty-five years, after which the number starts to decline steadily and this process continues until the end of human life.
Today, scientists can say that changes in the formation of melatonin in the course of life are not a coincidence with the stages of development of the organism. They are organically bound up with them and have a direct impact on physiological processes. Unfortunately, the information on all the most important discoveries of the fragments is published in some scientific journals.
In the study of physiological properties of melatonin involves scientists from different fields of medicine - cardiologists, oncologists, pediatricians, gerontologists, chronobiology and immunology. And the results are of great interest.
It appeared that melatonin has a hypnotic effect. Surprisingly, sleep is even a very small dose of only 0.1. Soon reports of the ability of melatonin to induce physiological sleep in humans appeared in specialized journals and the many thousands of insomniacs people hope to abandon the traditional sleeping pills with a number of side toxic effects. It is very important that melatonin preserves the natural structure of sleep, and restores it if it is broken. On the basis of actual data, we can say that melatonin can be particularly important in the restoration of the natural physiological functions of the body for those who have a low levels, hereditary or due to poor lifestyle, and therefore, quite early having trouble sleeping. And of course it is not only older people.
Hypnotic properties of melatonin seem quite closely linked with another of his unique ability. All of whom often have to change the time mode, know how difficult it is to adapt to the new rhythm of the day. It turned out that melatonin is many times reduces all unpleasant consequences. It not only helps a person to sleep on time, but also rebuilds all the biological rhythms of the body in accordance with a new schedule in local time. A lot of people were enthusiastic about such a wonderful news - tourists, businessmen, crews of the air ships and melatonin has become a mandatory part of their Luggage. But such problems are very familiar, and many other people - doctors ambulance, shift work, experimenters, and anyone who often has to sit at night for an urgent work.
Every year many of us suffer from flu, and many other infectious diseases. Doctors are constantly searching for various ways to boost the immunity of people to help them prevent diseases. There is hope that melatonin may prove a very effective immune stimulant. Immunologists have discovered that increasing the activity of T - and b - immune cells during the day takes place in parallel with increasing concentrations of melatonin. It was found that melatonin is involved in the regulation of the function of the thymus and thyroid glands, increases the activity of T-cells and phagocytes. Special value of these properties are for those suffering from primary and secondary immunodeficiency.
But the function of the immune system is not only the immediate protection of the organism against viruses and bacteria. No less important is its ability to distinguish "their" cells from "foreign". Violation of this ability leads to autoimmune diseases. A very important role in melatonin and immune system support during times of stress, whatever the cause of its cause.
Although the influence of melatonin on the immune system are not yet fully understood, however, today immunologists suggest that it can be used to accelerate wound healing, to maintain the body's resistance to colds and infectious diseases. Possibly in the near future suffering from cancer will get the hope to alleviate their condition and to mitigate the negative effects of chemotherapy and radiation, maintain your immune status.
In addition to oncological diseases, still one of the most promising implementations of melatonin in the practice are diseases of the cardiovascular system. In recent years, this disease has become much "younger". Whatever the reason for their development (poor diet, lifestyle, etc.) melatonin can be used to prevent diseases of the cardiovascular system, and maybe therapy.
As you know, cholesterol is found in many foods and is required and very important player metabolism. But if the number exceeds the norm, especially as it relates to cholesterol low density, it can initiate the formation of atherosclerotic plaques on the inner walls of blood vessels. The pilot studies have shown that melatonin inhibits this process. Scientists have found that melatonin supplements reduce the amount of "bad" cholesterol in the blood. Most likely this is due to the fact that it is involved in the regulation of the thyroid gland. The hormones it produces are involved in metabolism and very important for the use and destruction of cholesterol. No less dangerous is hypertension, or high blood pressure, and melatonin alleviates hypertensive crises. Studies have shown that regular use of melatonin helps to reduce the pressure in hypertensive patients.
Throughout the research time of melatonin he was regarded as one of the hormones that is very poorly understood. And only in 1992 it turned out that it performs other important functions. Nature has developed the human protection mechanisms against free radicals, which according to doctors and biologists are the cause of many dangerous diseases. The list of our own defenders, you can enable and melatonin. Comparing its effect with other substances that are traditionally used as antioxidants - vitamins E and C, beta-carotene, etc. - scientists have found that melatonin at least twice as active as vitamin E, five times as effective as glutathione at neutralizing the hydroxyl radical, the most active of all the free radicals and almost five hundred times more active than the best synthetic antioxidants, which are used traditionally for protection against radiation.
We reviewed the most important properties of melatonin and now I would like to make a small conclusion. So, what do we come from? With age the body gradually loses its melatonin. We take for granted the fact that elderly people suffering from insomnia, that he has increased pressure, eye drops, increased bone fragility, sclerosis develops, impaired memory. No one is surprised when the old man gets cancer, diabetes, arthritis or osteoporosis. Man after forty will be automatically included in the risk group for cardiovascular disease, benign prostatic hyperplasia; women after the age of thirty begin to fear the development of breast cancer, and after forty-five many already entering menopause. Many foreign researchers melatonin today suggest that this substance is able to extend the activity of the organism and, moreover, to increase life expectancy. You will need more than a dozen years to make sure that this is really happening people. While such results were obtained only in experimental conditions. However, they are quite convincing, as in the experiments by Italian scientists, life expectancy of laboratory mice and rats that took melatonin, increased by 15-25%. As for humans, it is possible to do is only indirect conclusions. For example, if we assume that melatonin actually has a positive effect on life expectancy, the longevity, the level of this hormone must be increased. However, Italian researchers have found indirect evidence that may be relevant to melatonin. Having studied immunological reactions of twenty-three persons, whose age exceeded one hundred years, they found they have a very active killer cells. Perhaps, this proactive activity of the immune system is the secret of longevity. In turn, melatonin stimulates the of these cells and, hence, its supplementation may indirectly affect life expectancy.
In favor of melatonin we can say the following. Conducting experiments on animals and then clinical trials in hospitals, the researchers still have not found any negative effects of the drug. Even a fairly large dose (about 300 mg) did not produce any negative side effects except some sleepiness the morning after a very high dose. Experiments show that melatonin acts very selectively, i.e. acting on something that requires exposure. For example, it reduces the level of cholesterol in the blood, but with no effect in this direction, if a person has the level of cholesterol in the normal range.
Already in the late 80's-early 90-ies has conducted several comparative studies in different countries and found that in women, the level of melatonin in average 25% higher than that of men. Of course, such experiments should continue, but it is already possible to suggest several mechanisms by which melatonin acts on the human lifespan:
1. Restores a healthy sleep.
2. Protects the cardiovascular system.
3. Stimulates an aging immune system.
4. Stabilizes the biological rhythms of the person.
5. Reduces the damaging effects of free radicals.
Studies of melatonin of course is still far from complete, scientists will discover many of the biological properties of this substance.<
Last edited by
Dimas on Mon Mar 03, 2008 15:40, edited 1 time in total.